E. A. Nikitin, Z. A. Ahmedova, M. A. Kolyvanova, N. S. Lifanovsky, A. V. Belousov, A. A. Markova, M. T. Nguyen, E. F. Shevtsova, K. A. Lyssenko, V. Yu. Tyurin, V. A. Kuzmin, V. N. Morozov, E. R. Milaeva, “Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors”, Mendeleev Commun., 35:4 (2025), 433

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Mendeleev Communications, 2025, Volume 35, Issue 4, Pages 433–436
DOI: https://doi.org/10.71267/mencom.7671 (Mi mendc7134)

Communications

Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors

E. A. Nikitin^a, Z. A. Ahmedova^a, M. A. Kolyvanova^abc, N. S. Lifanovsky^b, A. V. Belousov^c, A. A. Markova^b, M. T. Nguyen^b, E. F. Shevtsova^d, K. A. Lyssenko^a, V. Yu. Tyurin^a, V. A. Kuzmin^b, V. N. Morozov^b, E. R. Milaeva^ad

^a Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation
^c Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency of the Russian Federation, 123098 Moscow, Russian Federation
^d Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

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DOI: https://doi.org/10.71267/mencom.7671

Graphic abstract: Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors

Abstract: New compounds consisting of 2,6-di-tert-butylphenol and isomeric pyridinecarboxamide moieties as well as their water-soluble hydrochlorides were synthesized. The compounds appeared to be potent antioxidants and radioprotectors, with no significant difference in activity between the pyridine bases and their salts. The cytotoxicity assay showed no significant toxic impact from any of the substances, making them promising candidates for further investigation.

Keywords: radioprotectors, antioxidants, radical scavengers, sterically hindered phenols, pyridinecarboxamides, circular dichroism.

Funding agency	Grant number
Russian Science Foundation	23-23-10030

Received: 29.10.2024
Accepted: 21.01.2025

Published: 21.05.2025

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.5 Mb)

Citation: E. A. Nikitin, Z. A. Ahmedova, M. A. Kolyvanova, N. S. Lifanovsky, A. V. Belousov, A. A. Markova, M. T. Nguyen, E. F. Shevtsova, K. A. Lyssenko, V. Yu. Tyurin, V. A. Kuzmin, V. N. Morozov, E. R. Milaeva, “Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors”, Mendeleev Commun., 35:4 (2025), 433–436

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