X. He, T. Yuan, J. Sui, Sh. Dong, Z. Wang, D. Liu, Y. Zou, “One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates”, Mendeleev Commun., 35:5 (2025), 530

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Mendeleev Communications, 2025, Volume 35, Issue 5, Pages 530–532
DOI: https://doi.org/10.71267/mencom.7748 (Mi mendc7281)

Communications

One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates

X. He^a, T. Yuan^a, J. Sui^b, Sh. Dong^a, Z. Wang^a, D. Liu^a, Y. Zou^c

^a School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P. R. China
^b Nanjing Customs Testing Center for Dangerous Goods and Packaging, 213100 Changzhou, P. R. China
^c Department of Medicinal Chemistry, China Pharmaceutical University, 210009 Nanjing, P. R. China

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DOI: https://doi.org/10.71267/mencom.7748

Graphic abstract: One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates

Abstract: A convenient one-pot synthesis of acetylated quinolines/isoquinolines/pyridines involves the sodium-promoted Claisen condensation of the corresponding ethyl hetarenecarboxylates with ethyl acetate as the reactant and the solvent. The thus formed intermediate ethyl 3-hetaryl-3-oxopropanoates can be decarboxylated in the same reactor by refluxing with 25% H₂SO₄ to afford the title products in good to excellent yields.

Keywords: acetylquinolines, acetylisoquinolines, acetylpyridines, acetylation, Claisen condensation, one-pot synthesis, solvent-free process.

Funding agency	Grant number
Research Fund of Changzhou Vocational Institute of Engineering

Received: 17.02.2025
Accepted: 14.03.2025

Published: 17.07.2025

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(3.7 Mb)

Citation: X. He, T. Yuan, J. Sui, Sh. Dong, Z. Wang, D. Liu, Y. Zou, “One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates”, Mendeleev Commun., 35:5 (2025), 530–532

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