V. B. Kharitonov, O. G. Chusova, I. O. Bekshaite, K. A. Vasiliev, A. N. Rodionov, Yu. V. Nelyubina, P. V. Dorovatovskii, D. A. Loginov, “Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework”, Mendeleev Commun., 35:5 (2025), 602

Mendeleev Communications

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Mendeleev Communications, 2025, Volume 35, Issue 5, Pages 602–605
DOI: https://doi.org/10.71267/mencom.7777 (Mi mendc7296)

This article is cited in 1 scientific paper (total in 1 paper)

Communications

Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework

V. B. Kharitonov^a, O. G. Chusova^a, I. O. Bekshaite^a, K. A. Vasiliev^a, A. N. Rodionov^a, Yu. V. Nelyubina^ab, P. V. Dorovatovskii^c, D. A. Loginov^a

^a A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation
^b Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
^c National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation

Full-text PDF (1180 kB) Citations (1) Supplementary materials

References:

PDF

HTML

DOI: https://doi.org/10.71267/mencom.7777

Graphic abstract: Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework

Abstract: A series of hydroxy- and alkoxy-substituted isocoumarins were synthesized in one step by the rhodium-catalyzed C–H annulation of benzoic acids with alkynes. 8,9-Diethyl-6H-[1,3]dioxolo[4,5-f]isochromen-6-one and its isoquinolone analog have effectively inhibited the growth of six types of phytopathogenic fungi at 30 mg dm^–3 concentration, the activity exceeding that of the commercial Triadimefon.

Keywords: antifungal agents, C–H activation, C–H annulation, isocoumarins, benzoic acids, alkynes, homogeneous catalysis, rhodium complexes.

Funding agency	Grant number
Russian Science Foundation	19-73-20212
Ministry of Science and Higher Education of the Russian Federation	contract/agreement no. 075-00276-25-00

Received: 21.04.2025
Accepted: 28.04.2025

Published: 17.07.2025

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(3.2 Mb)

Citation: V. B. Kharitonov, O. G. Chusova, I. O. Bekshaite, K. A. Vasiliev, A. N. Rodionov, Yu. V. Nelyubina, P. V. Dorovatovskii, D. A. Loginov, “Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework”, Mendeleev Commun., 35:5 (2025), 602–605

Linking options:

https://www.mathnet.ru/eng/mendc7296

https://www.mathnet.ru/eng/mendc/v35/i5/p602

This publication is cited in the following 1 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Registration to the website

Logotypes