N. S. Volkova, A. A. Larenkov, N. S. Boutakova, E. K. Beloglazkina, A. E. Machulkin, “Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA”, Mendeleev Commun., 35:6 (2025), 670

Mendeleev Communications

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Mendeleev Communications, 2025, Volume 35, Issue 6, Pages 670–672
DOI: https://doi.org/10.71267/mencom.7764 (Mi mendc7315)

Communications

Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA

N. S. Volkova^a, A. A. Larenkov^b, N. S. Boutakova^a, E. K. Beloglazkina^a, A. E. Machulkin^a

^a Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russian Federation

Full-text PDF (438 kB) Supplementary materials

References:

PDF

HTML

DOI: https://doi.org/10.71267/mencom.7764

Graphic abstract: Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA

Abstract: Conjugate containing fragments of pteroic acid, anti-inflammatory drug ibuprofen, macrocyclic chelator DOTA-GA and (His-Glu)₂ moiety has been synthesized. Key structural motifs of this compound were introduced to optimize the pharmacokinetic characteristics of the pteroic acid-based conjugate. The complexation of the conjugate with radioactive lutetium-177 provided radiochemical yield of >99% and radiochemical purity of 97.6%.

Keywords: folate receptors, conjugates, delivery, peptide, pteroic acid, peptide synthesis, DOTA-GA.

Funding agency	Grant number
The state assignment of Lomonosov Moscow State University	AAAA-A21-121012290046-4
Russian Science Foundation	22-15-00098-P

Received: 14.03.2025
Accepted: 04.07.2025

Published: 21.10.2025

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(3.2 Mb)

Citation: N. S. Volkova, A. A. Larenkov, N. S. Boutakova, E. K. Beloglazkina, A. E. Machulkin, “Synthesis of a pteroic-based conjugate with ibuprofen moiety and macrocyclic chelator DOTA-GA”, Mendeleev Commun., 35:6 (2025), 670–672

Linking options:

https://www.mathnet.ru/eng/mendc7315

https://www.mathnet.ru/eng/mendc/v35/i6/p670

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Registration to the website

Logotypes