Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin

Chiral hydrogen-bonded organic frameworks incorporating proline motifs were synthesized from tetrakis-, bis- or monoprolinamide precursors and di- or tetracarboxylic or sulfonic acids. Their testing as heterogeneous catalysts for the synthesis of warfarin provided product yields of up to 84% with ee values of up to 45%.