V. V. Spiridonov, K. S. Sadovnikov, D. A. Vasilenko, K. N. Sedenkova, A. R. Lukmanova, A. A. Markova, A. V. Shibaeva, A. V. Bolshakova, S. S. Karlov, E. B. Averina, A. A. Yaroslavov, “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate”, Mendeleev Commun., 32:5 (2022), 591

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Mendeleev Communications, 2022, Volume 32, Issue 5, Pages 591–593
DOI: https://doi.org/10.1016/j.mencom.2022.09.007 (Mi mendc735)

This article is cited in 7 scientific papers (total in 7 papers)

Communications

Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca²⁺ (Mg²⁺) cross-linked alginate

V. V. Spiridonov^a, K. S. Sadovnikov^a, D. A. Vasilenko^a, K. N. Sedenkova^a, A. R. Lukmanova^b, A. A. Markova^cd, A. V. Shibaeva^c, A. V. Bolshakova^a, S. S. Karlov^a, E. B. Averina^a, A. A. Yaroslavov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Department of Materials Science, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
^d A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Full-text PDF (740 kB) Citations (7) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2022.09.007

Graphic abstract: Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca<sup>2+</sup> (Mg<sup>2+</sup>) cross-linked alginate

Abstract: Water-dispersible complexes of 4-methyl-N-[5-methyl-3-(3,4,5-trimethoxyphenyl)isoxazol-4-yl]benzamide possessing anticancer activity were prepared by its immobilization with biocompatible polymer nanocontainers based on sodium alginate cross-linked with Ca²⁺ and Mg²⁺ ions. It was found that this isoxazole derivative retains its structure during immobilization. Colloidal stable nanocontainers filled with this compound exhibit toxicity toward the colon carcinoma (HCT116) tumor cell line.

Keywords: polysaccharide nanocontainers, alginate, 4-acylaminoisoxazoles, colloidal stability, anticancer activity.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(467.6 Kb)

Citation: V. V. Spiridonov, K. S. Sadovnikov, D. A. Vasilenko, K. N. Sedenkova, A. R. Lukmanova, A. A. Markova, A. V. Shibaeva, A. V. Bolshakova, S. S. Karlov, E. B. Averina, A. A. Yaroslavov, “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca²⁺ (Mg²⁺) cross-linked alginate”, Mendeleev Commun., 32:5 (2022), 591–593

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https://www.mathnet.ru/eng/mendc/v32/i5/p591

This publication is cited in the following 7 articles:

Citing articles in Google Scholar: Russian citations, English citations
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