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Mendeleev Communications, 2021, Volume 31, Issue 2, Pages 204–206
DOI: https://doi.org/10.1016/j.mencom.2021.03.019
(Mi mendc879)
 

This article is cited in 18 scientific papers (total in 18 papers)

Communications

Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

S. N. Adamovich, E. Kh. Sadykov, I. A. Ushakov, E. N. Oborina, L. A. Belovezhets

A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation
Abstract: Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R1=R2=R3=H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.
Keywords: silatranes, pyrrolecarboxamides, hybrids, antitumor activity, antimicrobial action.
Bibliographic databases:
Document Type: Article
Language: English
Supplementary materials:
Supplementary_data_1.pdf (979.2 Kb)


Citation: S. N. Adamovich, E. Kh. Sadykov, I. A. Ushakov, E. N. Oborina, L. A. Belovezhets, “Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids”, Mendeleev Commun., 31:2 (2021), 204–206
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  • https://www.mathnet.ru/eng/mendc/v31/i2/p204
  • This publication is cited in the following 18 articles:
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