Abstract:
Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R1=R2=R3=H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.
Citation:
S. N. Adamovich, E. Kh. Sadykov, I. A. Ushakov, E. N. Oborina, L. A. Belovezhets, “Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids”, Mendeleev Commun., 31:2 (2021), 204–206
Linking options:
https://www.mathnet.ru/eng/mendc879
https://www.mathnet.ru/eng/mendc/v31/i2/p204
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