N. E. Borisova, M. A. Orlova, V. A. Knizhnikov, V. K. Dolgova, M. D. Reshetova, A. P. Orlov, “First 97Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical”, Mendeleev Commun., 31:2 (2021), 207

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Mendeleev Communications, 2021, Volume 31, Issue 2, Pages 207–209
DOI: https://doi.org/10.1016/j.mencom.2021.03.020 (Mi mendc880)

This article is cited in 9 scientific papers (total in 9 papers)

Communications

First ⁹⁷Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical

N. E. Borisova^a, M. A. Orlova^ab, V. A. Knizhnikov^c, V. K. Dolgova^a, M. D. Reshetova^a, A. P. Orlov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^c Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

Full-text PDF (254 kB) Citations (9) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.03.020

Graphic abstract: First <sup>97</sup>Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical

Abstract: A new peptidomimetic conjugate of natural methionine and pyridine-2,6-dicarboxylate was synthesized and evaluated as a potential ligand for ⁹⁷Ru radiopharmaceuticals. The distribution of this radiopharmaceutical in mice was investigated. A fundamental difference was found in the distribution and excretion of ruthenium complex and free ruthenium ion in the body, which suggests a difference in their transport pathways due to the stability of the complex in the body.

Keywords: ruthenium-97, mouse model, clearance, pyridine-2,6-dicarboxamide, conjugates, radioactivity.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(935.2 Kb)

Citation: N. E. Borisova, M. A. Orlova, V. A. Knizhnikov, V. K. Dolgova, M. D. Reshetova, A. P. Orlov, “First ⁹⁷Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical”, Mendeleev Commun., 31:2 (2021), 207–209

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https://www.mathnet.ru/eng/mendc880

https://www.mathnet.ru/eng/mendc/v31/i2/p207

This publication is cited in the following 9 articles:

Citing articles in Google Scholar: Russian citations, English citations
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