E. V. Verbitskiy, S. A. Baskakova, D. V. Belyaev, D. V. Vakhrusheva, N. I. Eremeeva, G. L. Rusinov, V. N. Charushin, “Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity”, Mendeleev Commun., 31:2 (2021), 210

Mendeleev Communications

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Mendeleev Communications, 2021, Volume 31, Issue 2, Pages 210–212
DOI: https://doi.org/10.1016/j.mencom.2021.03.021 (Mi mendc881)

This article is cited in 13 scientific papers (total in 13 papers)

Communications

Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity

E. V. Verbitskiy^ab, S. A. Baskakova^a, D. V. Belyaev^ac, D. V. Vakhrusheva^c, N. I. Eremeeva^c, G. L. Rusinov^ab, V. N. Charushin^ab

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
^c Ural Research Institute for Phthisiopulmonology, Ekaterinburg, Russian Federation

Full-text PDF (245 kB) Citations (13) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.03.021

Graphic abstract: Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity

Abstract: The Buchwald–Hartwig cross-coupling of 5-bromo-4-(furan-2-yl)pyrimidine with various anilines afforded the corresponding new 5-(arylamino)pyrimidines, the reaction being accelerated by microwave irradiation. Most of the obtained compounds proved to possess a high bacteriostatic in vitro effect against Mycobacterium tuberculosis H₃₇Rv, Neisseria gonorrhoeae, and Staphylococcus aureus including Methicillin-resistant strain, which is stronger than that of the commercial drug Spectinomycin.

Keywords: pyrimidines, nitrofurans, anti-mycobacterial activity, Buchwald–Hartwig amination, cross-coupling reactions.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.3 Mb)

Citation: E. V. Verbitskiy, S. A. Baskakova, D. V. Belyaev, D. V. Vakhrusheva, N. I. Eremeeva, G. L. Rusinov, V. N. Charushin, “Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity”, Mendeleev Commun., 31:2 (2021), 210–212

Linking options:

https://www.mathnet.ru/eng/mendc881

https://www.mathnet.ru/eng/mendc/v31/i2/p210

This publication is cited in the following 13 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Registration to the website

Logotypes