M. J. Parulava, Yu. N. Kotovshchikov, G. V. Latyshev, D. V. Sokolova, I. P. Beletskaya, N. V. Lukashev, “Synthesis of novel cytotoxic 3-azolylsteroids via Cu-catalyzed C–N coupling”, Mendeleev Commun., 31:3 (2021), 359

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Mendeleev Communications, 2021, Volume 31, Issue 3, Pages 359–361
DOI: https://doi.org/10.1016/j.mencom.2021.04.025 (Mi mendc929)

This article is cited in 3 scientific papers (total in 3 papers)

Communications

Synthesis of novel cytotoxic 3-azolylsteroids via Cu-catalyzed C–N coupling

M. J. Parulava^a, Yu. N. Kotovshchikov^a, G. V. Latyshev^a, D. V. Sokolova^bc, I. P. Beletskaya^a, N. V. Lukashev^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Full-text PDF (236 kB) Citations (3) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.04.025

Graphic abstract: Synthesis of novel cytotoxic 3-azolylsteroids <i>via</i> Cu-catalyzed C–N coupling

Abstract: A series of novel 3-azolylandrosta-3,5-dienes was prepared via Cu-catalyzed Ullmann C–N coupling between a readily available steroidal vinyliodide and a variety of NH-heterocycles. The cytotoxic activity of the target compounds was evaluated against selected cancer cell lines (MCF-7, SKOV-3, DU-145, PC-3). Compound bearing gramine fragment showed the highest antiproliferative effect with IC₅₀ values in the range of 2.0–10.1μm.

Keywords: steroids, copper catalysis, nitrogen heterocycles, iodoalkenes, antiproliferative activity, MTT assay.

Bibliographic databases:

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(851.8 Kb)

Citation: M. J. Parulava, Yu. N. Kotovshchikov, G. V. Latyshev, D. V. Sokolova, I. P. Beletskaya, N. V. Lukashev, “Synthesis of novel cytotoxic 3-azolylsteroids via Cu-catalyzed C–N coupling”, Mendeleev Commun., 31:3 (2021), 359–361

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https://www.mathnet.ru/eng/mendc929

https://www.mathnet.ru/eng/mendc/v31/i3/p359

This publication is cited in the following 3 articles:

Citing articles in Google Scholar: Russian citations, English citations
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