E. Yu. Levashova, A. A. Firsov, O. Yu. Bakulina, A. A. Peshkov, E. V. Kanov, R. R. Gainetdinov, M. Yu. Krasavin, “Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)”, Mendeleev Commun., 31:4 (2021), 488

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Mendeleev Communications, 2021, Volume 31, Issue 4, Pages 488–489
DOI: https://doi.org/10.1016/j.mencom.2021.07.016 (Mi mendc964)

This article is cited in 8 scientific papers (total in 8 papers)

Communications

Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)

E. Yu. Levashova^a, A. A. Firsov^a, O. Yu. Bakulina^a, A. A. Peshkov^a, E. V. Kanov^a, R. R. Gainetdinov^a, M. Yu. Krasavin^ab

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation

Full-text PDF (174 kB) Citations (8) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.07.016

Graphic abstract: Rare <i>cis</i>-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)

Abstract: Rare cis-configured 2,4-disubstituted 1-alkylpyridines were envisioned as ligands for trace amine associated receptor 1 (TAAR1). They were synthesized in diastereomerically pure form with the decarboxylative Castagnoli–Cushman reac-tion followed by two reduction events. Despite showing no affinity to TAAR1 as was anticipated, these novel, druglike and CNS-focused compounds will be of much utility in sub-sequent lead generation pursuits.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.7 Mb)

Citation: E. Yu. Levashova, A. A. Firsov, O. Yu. Bakulina, A. A. Peshkov, E. V. Kanov, R. R. Gainetdinov, M. Yu. Krasavin, “Rare cis-configured 2,4-disubstituted 1-alkylpiperidines: synthesized and tested against trace-amine-associated receptor 1 (TAAR1)”, Mendeleev Commun., 31:4 (2021), 488–489

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https://www.mathnet.ru/eng/mendc/v31/i4/p488

This publication is cited in the following 8 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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