Abstract:
Glycosylation of lactosamine acceptors with Kdn thioglycoside donors in the presence of NIS/TfOH as a promoter affords products with both α- and β-ketosidic linkage (2–6' or 2–3') between the Kdn and Gal residues. After deprotection, the synthesized trisaccharides and glycans containing Neu5Ac were printed to a chip and their comparative interaction with human serum antibodies was explored.
Citation:
A. A. Chinarev, M. A. Sablina, R. A. Kunetsky, N. V. Shilova, S. M. Polyakova, A. S. Paramonov, J. Saha, N. V. Bovin, “Synthesis of spacer armed Kdn(2→6') and (2→3')-lactosamines for immunochemical research”, Mendeleev Commun., 31:4 (2021), 490–492
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https://www.mathnet.ru/eng/mendc965
https://www.mathnet.ru/eng/mendc/v31/i4/p490
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