J. Sun, L. He, Yu. Gao, L. Zhai, J. Ji, Yu. Liu, J. Ji, X. Ma, Ya. Mu, D. Tang, H. Yang, Z. Iqbal, Zh. Yang, “Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem”, Mendeleev Commun., 31:4 (2021), 498

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Mendeleev Communications, 2021, Volume 31, Issue 4, Pages 498–500
DOI: https://doi.org/10.1016/j.mencom.2021.07.020 (Mi mendc968)

This article is cited in 10 scientific papers (total in 10 papers)

Communications

Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem

J. Sun^a, L. He^a, Yu. Gao^a, L. Zhai^a, J. Ji^a, Yu. Liu^a, J. Ji^a, X. Ma^b, Ya. Mu^a, D. Tang^a, H. Yang^a, Z. Iqbal^a, Zh. Yang^a

^a Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, Ningxia, P.R. China
^b College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, P.R. China

Full-text PDF (214 kB) Citations (10) Supplementary materials

DOI: https://doi.org/10.1016/j.mencom.2021.07.020

Graphic abstract: Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem

Abstract: New avibactam derivatives in which amide moiety is replaced by substituted amidine groupings were obtained in several steps, the key step having involved the conversion of 2-positioned cyano group of the 1,6-diazabicyclo[3.2.1]-octane framework into the amidine one. Synergistic antibacterial activity of the new compounds in combination with meropenem infers the agonistic effect of these derivatives against β-lactamases.

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Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(717.5 Kb)

Citation: J. Sun, L. He, Yu. Gao, L. Zhai, J. Ji, Yu. Liu, J. Ji, X. Ma, Ya. Mu, D. Tang, H. Yang, Z. Iqbal, Zh. Yang, “Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem”, Mendeleev Commun., 31:4 (2021), 498–500

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This publication is cited in the following 10 articles:

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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