Conjugated pyrrole/aminoenone and pyrrole/aminoacrylonitrile ensembles: new motives in heterocyclic chemistry

Methods for the preparation of two highly flexible synthetic building blocks, namely pyrrole/aminoenone and pyrrole/aminoacrylonitrile ensembles, on the basis of available starting materials such as 2-acylethynylpyrroles or pyrrole-2-carbodithioates, are summarized. The presence of several reactive centers in their molecules (pyrrole ring, enamine and carbonyl or nitrile moieties) ensures their multiple reactivity and application as versatile intermediates in the synthesis of heterocyclic ensembles such as pyrrolyl pyridines, bipyrroles, pyrrolyl-isoxazoles and condensed compounds, such as pyrrolo[3,2-a]pyrazines, pyrrolizines, which have high potential for use in medical chemistry and materials science.