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This article is cited in 4 scientific papers (total in 4 papers)
Studying the sensitivity of graphene for biosensor applications
A. S. Usikovab, S. P. Lebedevc, A. D. Roenkovd, I. S. Barashcd, S. V. Novikove, M. V. Puzykf, A. V. Zubova, Yu. N. Makarovb, A. A. Lebedevc a St. Petersburg National Research University of Information Technologies, Mechanics and Optics
b Nitride Crystals, Inc., Richmond, USA
c Ioffe Institute, St. Petersburg
d Nitride Crystals Group, St. Petersburg, Russia
e Aalto University, Espoo, Finland
f Herzen State Pedagogical University of Russia, St. Petersburg
Abstract:
We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (С$_{20}$Н$_{12}$О$_{5}$) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 $\times$ 10$^{-3}$ to 1 $\times$ 10$^{4}$ ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.
Keywords:
graphene, silicon carbide, biosensor, fluorescein.
Received: 17.02.2020 Revised: 17.02.2020 Accepted: 18.02.2020
Citation:
A. S. Usikov, S. P. Lebedev, A. D. Roenkov, I. S. Barash, S. V. Novikov, M. V. Puzyk, A. V. Zubov, Yu. N. Makarov, A. A. Lebedev, “Studying the sensitivity of graphene for biosensor applications”, Pisma v Zhurnal Tekhnicheskoi Fiziki, 46:10 (2020), 3–6; Tech. Phys. Lett., 46:5 (2020), 462–465
Linking options:
https://www.mathnet.ru/eng/pjtf5095 https://www.mathnet.ru/eng/pjtf/v46/i10/p3
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