Energetics of bimolecular nucleophilic reactions in solution

Published data on the activation parameters of bimolecular nucleophilic reactions in solution are generalised and described systematically. The factors that influence the relation between the activation parameters in these reactions are discussed. The relationships between the mechanisms of bimolecular nucleophilic substitution and addition reactions and their activation parameters are considered, and the role of the enthalpy–entropy compensation effect is analysed.