Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

Diabetes and complications derived are among serious global health concerns that critically deteriorate the quality of patient life and in some cases result in lethal outcome. Herein, general information on the pathogenesis, factors aggravating the course of the disease and drugs used for the treatment of two types of diabetes are briefly discussed. The aim of the review is to introduce supramolecular strategies that are currently being developed for the treatment of diabetes mellitus and are very effective alternative to chemical synthesis, which allows for fabrication of nanocontainers with switchable characteristics answering green chemistry criteria. Particular attention is paid to organic (amphiphilic and polymeric) formulations, including naturally driven compositions due to their biocompatibility, low toxicity, and bioavailability. Advantages and limitations of different nanosystems are discussed, with their adaptivity to noninvasive administration routes emphasized.
The bibliography includes 378 references.