Peculiarities of Drosophila melanogaster adaptive reaction to a benzazolide genotoxicity of various molecular structure

It was found out that benzimidazole and its derivatives authentically differ in their ability to induce dominant lethal mutations at Drosophila melanogaster both in semilethal, and in nontoxical doses as well. Drosophila fly males are more sensitive to a mutagen benzimidazole action, than females. Mutagenecity correlated negatively with values of the molecular weight and molecular volume, and positively – with value of the hydration energy. Short-term and long-term influence by a nontoxical dose of substances are analyzed, a preadaptation to the subsequent genotoxic action of substances in dose LD50 is created. A preadaptation possibility by a benzimidazole nontoxical dose to its derivatives genotoxicity have been revealed.