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CHEMISTRY AND MATERIAL SCIENCE
Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro
O. Shydlovskaa, E. Kharchenkob, N. Zholobaka, A. Shcherbakova, A. Maryninb, O. Ivanovac, A. Baranchikovc, V. Ivanovcd a Zabolotny Institute of Microbiology and Virology NANU, Kyiv, Ukraine
b National University of Food Technologies, Kyiv, Ukraine
c Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia
d National Research Tomsk State University, Tomsk, Russia
Аннотация:
Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-$\alpha$ and recombinant tumor necrosis factor-$\alpha$-thymosin-$\alpha$1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.
Ключевые слова:
cerium oxide nanoparticles, tumor necrosis factor, nano-biocomposite, biological activity, antitumor effect.
Поступила в редакцию: 02.05.2018 Исправленный вариант: 18.06.2018
Образец цитирования:
O. Shydlovska, E. Kharchenko, N. Zholobak, A. Shcherbakov, A. Marynin, O. Ivanova, A. Baranchikov, V. Ivanov, “Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro”, Наносистемы: физика, химия, математика, 9:4 (2018), 537–543
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/nano341 https://www.mathnet.ru/rus/nano/v9/i4/p537
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