Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units

Novel mono- and bis(2H-chromen-2-imine) hybrids linked to different heteroarene units were prepared by cyclocondensation of 2-hydroxybenzaldehydes with 2-heteroarylacetonitriles. Their in vitro antibacterial activities against different strains of Gram-positive and negative bacteria were assessed. Piperazine-linked bis(3-heteroaryl-2Hchromen-2-imines) exhibited the best antibacterial efficacies against E. coli, S. aureus and S. mutans strains with MIC values of 1.4–20.8μm.