Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications

The design and synthesis of lipidic organoalkoxysilanes with different higher fatty acids as hydrophobic acyl chains for the construction of bilayer vesicles called ‘cerasomes’ were accomplished and their properties, including hydrodynamic diameter, zeta potential and encapsulation efficiency of water-soluble doxorubicin, were determined. Experiments have shown that an asymmetric hydrophobic block makes it possible to obtain cerasomes with acceptable size and stability. At the same time, the drug loading is quite high.