Аннотация:
Eight cinnamic acid derivatives were studied as prion inhibitors in vitro and their cytotoxicity was evaluated. Ferulic (3-methoxy-4-hydroxycinnamic) acid, 3,4,5-trimethoxycin- namic acid and methyl 3-ethoxy-4-acetamidoxycinnamate were found to inhibit amyloid fibril formation, seeding, and spontaneous aggregation of recombinant ovine prion protein. None of the compounds demonstrated cytotoxicity on human neuroblastoma SH-SY5Y cells.
Реферативные базы данных:
Тип публикации:
Статья
Язык публикации: английский
Образец цитирования:
S. A. Tishina, V. S. Stroylov, I. A. Zanyatkin, A. K. Melnikova, V. I. Muronetz, Yu. Yu. Stroylova, “Cinnamic acid derivatives as the potential modulators of prion aggregation”, Mendeleev Commun., 27:5 (2017), 493–494