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Эта публикация цитируется в 10 научных статьях (всего в 10 статьях)
Rational design and synthesis of novel Syk-kinase inhibitors
A. A. Zeifmana, I. Yu. Titovab, I. Svitankob, T. V. Rakitinacd, A. V. Lipkinde, V. S. Stroylovab, O. V. Stroganovab, F. N. Novikova, G. G. Chilovab
a MolTech Ltd, Moscow, Russian Federation
b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
c M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
e A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation
Аннотация:
Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50 = 230±10 nM
Образец цитирования:
A. A. Zeifman, I. Yu. Titov, I. Svitanko, T. V. Rakitina, A. V. Lipkin, V. S. Stroylov, O. V. Stroganov, F. N. Novikov, G. G. Chilov, “Rational design and synthesis of novel Syk-kinase inhibitors”, Mendeleev Commun., 22:2 (2012), 73–74
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2743 https://www.mathnet.ru/rus/mendc/v22/i2/p73
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