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Эта публикация цитируется в 3 научных статьях (всего в 3 статьях)
Synthesis of trisaccharide 6’ SiaLec and its 6-O-Su derivative
G. V. Pazynina, I. S. Popova, I. M. Belyanchikov, A. B. Tuzikov, N. V. Bovin
M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
Аннотация:
The synthetic approach to 6'SiaLec and its 6-O-Su derivative comprised α-sialylation of a protected Lec derivative, 2,3-di-OAcGalβ1-3(3-OAc-6-OBn)GlcNAcβ1-Osp (68% yield) as the key stage. Deprotection of the obtained trisaccharide (three stages, 79% overall yield) led to Neu5Acα2-6Galβ1-3GlcNAcβ1-Osp; partial deprotection followed by selective sulfation and total deprotection – to Neu5Acα2-6Galβ1-3(6-O-Su)GlcNAcβ1-Osp (four stages, 72% overall yield).
Ключевые слова:
Lewis C trisaccharide, sulfation, sialylation.
Образец цитирования:
G. V. Pazynina, I. S. Popova, I. M. Belyanchikov, A. B. Tuzikov, N. V. Bovin, “Synthesis of trisaccharide 6’ SiaLec and its 6-O-Su derivative”, Mendeleev Commun., 22:4 (2012), 194–195
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2787 https://www.mathnet.ru/rus/mendc/v22/i4/p194
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