Chemoenzymatic synthesis of optically active phosphinic analogues of S-substituted sulfur-containing amino acids

The interaction of racemic 1-amino-3-(methylthio)propylphosphinic acid with benzylthiol catalysed by pyridoxal-5’-phosphatedependent L-methionine-γ-lyase affords (R)-1-amino-3-(benzylthio)propylphosphinic acid, which was converted into the (R)-isomers of phosphinic analogues of homocysteine and methionine.