Highly diastereocelective one-pot four-component coupling of p-TolSCI, 1-methoxycycloalkene, methyl vinyl ether and a carbon nucleophile leading to the synthesis of polyfunctional compounds

An one-pot TiCl₄ initiated assemblage of polyfunctional compounds via a sequential coupling of p-TolSCl, 1-methoxycycloalkene, methyl vinyl ether and Sn- or Si-capped carbon nucleophile is shown to proceed with high diastereoselectivity at all newly created chiral centres.