The Effect of Chloride on the Electroreduction of NAD+ in the Presence of [Cp*RhIII]2+ Species

A cyclic voltammetry study of the η⁵-pentamethylcyclopentadienylrhodium (Cp*Rh) complexes [(Cp*Rh)₂(μ.-Cl)₃]⁺ and [Cp*Rh^III_aq]²⁺ at pH 6.05 in the absence and in the presence of nicotinamide cofactors indicates that the chloro complex is more advantageous for electrochemical reduction of NAD⁺ into NADH; the reverse oxidation of NADH by [(Cp*Rh)₂(μ-CI)₃]⁺ is insufficiently selective for practical applications according to the ¹H NMR data.