Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units

A three-component tandem protocol involving the reactions of bis(benzohydrazides), aromatic aldehydes and chloramine trihydrate yielded a new series of bis(1,3,4-oxadiazoles). The target hybrids were formed by an initial bis(N-benzoyl-hydrazones) formation, followed by chloramine trihydrate- mediated oxidative cyclization. The 4-methoxyphenyl-containing compounds demonstrated promising antibacterial activity against the Staphylococcus aureus and Pseudomonas aeruginosa strains with MIC value of 1.6 µm.