Аннотация:
The supramolecular complexation of anthracycline antibiotic ruboxyl with water-soluble fullerene derivative was visualized by scattering scanning near-field optical microscopy, and the effects of this complexation on the antileukemic activity in vivo were evaluated. Treatment of mice with P388 lymphocytic leukemia with ruboxyl resulted in 13% of cured animals, while similar treatment with ruboxyl–fullerene derivative combination caused 63% curing.
Ключевые слова:
water-soluble fullerene derivative, ruboxyl, leukemia, vesicles, IR s-SNOM.
Образец цитирования:
O. A. Kraevaya, E. A. Khakina, N. A. Emelianov, A. F. Shestakov, T. E. Sashenkova, D. V. Mishchenko, P. A. Troshin, “Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance”, Mendeleev Commun., 34:2 (2024), 178–180