Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series

A series of bis-amides of bis(aminoalkyl)benzenes and diaminoalkanes were synthesized. Positive modulation of kainate-induced transmembrane currents was registered on Purkinje neurons for isobutyric acid derivative with 1,4-bis(aminomethyl)benzene linker (40% potentiation at 1nm). This compound also demonstrated a neuroprotective effect at 0.1nm in an oxidative stress model in HT-22 cells when applied 24h before H₂O₂.